This Hour Has America's 22 Minutes/Cast and list of guest stars

Despite being a comedy sketch show, Mary Walsh stated that This Hour Has America's 22 Minutes is not a direct competitor to ' and to ', due to the fact of airing in different days and having different running times, despite being influenced by both shows and ironically having former cast members from both. Unlike the Canadian version, the show never used false names to its anchors/correspondents. The show is also slighty influenced by 's .

Current members

 * since 2020, main anchor
 * since 2020, anchor/impersonator/voice actress
 * since 2020, anchor/impersonator
 * since 2020, anchor/reporter/voice actress
 * Luc Katzenellenbogen: since 2020, anchor/reporter/impersonator/voice actor
 * since 2020, anchor/reporter/impersonator
 * since 2010, anchor/impersonator/voice actress
 * since 2013, anchor/reporter/rapper
 * since 2012, reporter/impersonator

Former members

 * 1996 to 2001, reporter/impersonator/voice actor, former  cast member, replaced by Phil LaMarr.
 * 1996 to 2010, anchor/impersonator/voice actress, cast member from the original show, replaced by Nancy Giles.
 * 1996 to 2004, reporter/impersonator/voice actress, former  cast member, replaced by Shannen Doherty.
 * 1996 to 2007, reporter/impersonator/voice actor, former  cast member, replaced by Frank Caliendo.
 * 1996 to 2009, reporter/impersonator/voice actor, former  cast member, replaced by Michael McDonald.
 * 2001 to 2013, reporter/impersonator/voice actor, former  cast member, replaced by MF Doom.
 * 1996 to 2017, main anchor, also co-creator and executive producer.
 * 2013 to 2017, substitute anchor/impersonator, former  cast member.
 * 2009 to 2017, reporter/impersonator, former  cast member.
 * 2007 to 2017, reporter/impersonator, former  cast member.
 * 2004 to 2017, reporter/impersonator/voice actress.
 * 2015 to 2017, reporter/impersonator/voice actor.