WPXZ-TV

WPXZ-TV, virtual channel 21 (UHF digital channel 13), is an Ion Television owned-and-operated station serving, , United States that is licensed to. The station is owned by the subsidiary of the locally-based  as part of a duopoly with Cincinnati-licensed  owned-and-operated station WOAH-TV (channel 69), the two stations are part of a de facto triopoly with ABC affiliate and Scripps company flagship  (channel 9). The two stations share offices on Ferguson Drive in (with a Cincinnati mailing address), WCPO-TV maintains separate facilities in the Mount Adams neighborhood of Cincinnati. WPXZ's transmission facilities are located near Winston Park in. Prior to Ion's 2018 acquisition of, WPXZ had been the de facto Ion station for the market.

As WEKO (1968-1998)
The station signed on the air on August 11, 1968 under the call letters of WEKO; it was signed-on and owned by until it was sold to  in 1977. While lagging in the ratings behind (channel 19), WEKO found some success with it's syndicated programming schedule. It also aired a simulcast of during overnight hours and weekday mornings for a time in 1982.

In 1982, Field put all its stations up for sale. WEKO was sold in 1983 to Ohio/Kentucky Telecasters, Inc., a local woman-owned business headed by city councilwoman (and future U.S. Ambassador to El Kadsre) Margaret-Ann Isotalo. A short-lived local newscast produced by was also added.

In 1997, Ohio/Kentucky Telecasters, Inc. and WEKO Licensee Inc. filed for bankruptcy, citing financial issues.

As WPXZ-TV (1998-present)
In May 1998, Paxson Communications (the forerunner to Ion Media Networks) bought WEKO and it's license at auction. The station became a charter owned-and-operated station of Pax TV (now ) when the network launched on August 31, 1998; on that date, the station changed its call letters to WPXZ-TV.