WPXZ-TV

WPXZ-TV, virtual channel 21 (UHF digital channel 13), is an Ion Television owned-and-operated station serving, , United States that is licensed to. The station is owned by the subsidiary of the locally-based  as part of a triopoly with Cincinnati-licensed  owned-and-operated station WOAH-TV (channel 69) and ABC affiliate and Scripps company flagship  (channel 9). WPXZ-TV and WOAH-TV share offices on Ferguson Drive in (with a Cincinnati mailing address), while WCPO-TV maintains separate facilities in the Mount Adams neighborhood of Cincinnati. WPXZ-TV and WOAH-TV share transmission facilities on the tower near Winston Park in. Prior to Ion's 2018 acquisition of, WPXZ had been the de facto Ion station for the market.

As WEKO (1968-1998)
The station signed on the air on August 11, 1968 under the call letters of WEKO; it was signed-on and owned by until it was sold to  in 1977. While lagging in the ratings behind (channel 19), WEKO found some success with it's syndicated programming schedule. It also aired a simulcast of during overnight hours and weekday mornings for a time in 1982.

In 1982, Field put all its stations up for sale. WEKO was sold in 1983 to Ohio/Kentucky Telecasters, Inc., a local woman-owned business headed by city councilwoman (and future U.S. Ambassador to El Kadsre) Margaret-Ann Isotalo. A short-lived local newscast produced by was also added.

In 1997, Ohio/Kentucky Telecasters, Inc. and WEKO Licensee Inc. filed for bankruptcy, citing financial issues.

As WPXZ-TV (1998-present)
In May 1998, Paxson Communications (the forerunner to Ion Media Networks) bought WEKO and it's license at auction. The station became a charter owned-and-operated station of Pax TV (now ) when the network launched on August 31, 1998; on that date, the station changed its call letters to WPXZ-TV.